Targeting Replicative Stress to Treat Hematological Disorders

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Targeting psychoemotional stress to treat prostate cancer.

E arlier epidemiological studies identified diet as a primary environmental factor that determines substantial differences in prostate cancer incidence and mortality between East Asian and West European societies. New data from experiments performed in tissue culture and with animal models as well as epidemiological studies suggest that psychoemotional stress could be a second environmental com...

متن کامل

Targeting Chk1 in the replicative stress response

in response to DnA damage or interference with DnA synthesis, transformed cells characteristically activate various checkpoints, which together comprise an important component of a complex signaling network that has been termed the DnA damage response (DDR). Checkpoints identified so far are classified in two ways: (1) cell cycle checkpoints: the G1/s, intra-s or s, and G2/M checkpoint; or (2) ...

متن کامل

Targeting glutamate uptake to treat alcohol use disorders

Alcoholism is a serious public health concern that is characterized by the development of tolerance to alcohol's effects, increased consumption, loss of control over drinking and the development of physical dependence. This cycle is often times punctuated by periods of abstinence, craving and relapse. The development of tolerance and the expression of withdrawal effects, which manifest as depen...

متن کامل

Targeting Interferon- to Treat Atherosclerosis

The chronic inflammatory nature of atherosclerotic disease is now widely appreciated. Abnormal deposition and oxidative modification of serum lipoproteins in arterial walls stimulates the recruitment of monocytes and their conversion into foam cells. Concurrently, both innate and adaptive immune responses are induced. Cytokines and growth factors produced as part of these responses lead to the ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Blood

سال: 2015

ISSN: 0006-4971,1528-0020

DOI: 10.1182/blood.v126.23.2419.2419